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[79] The skilled person will appreciate that even though the pharmaceutical composition effectively provides for stabilization of the active ingredient (i.e

All animal procedures were approved by the Ethics Animal Care and Use Committee of the Institute of Biomedical Sciences, University of Sao Paulo

Although liver transplantation offers a curative approach for B6 non-respondents, it carries notable challenges, including surgical risks, the need for prolonged immunosuppression and limited donor availability

Importantly, because apoptotic death unfolds over hours to days, penumbral neurons remain vulnerable yet amenable to rescue during this window

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